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Cattle Drive Casserole: A Hearty and Flavorful Family Favorite


Cattle Drive Casserole is a comforting, savory dish that brings together the rich flavors of ground beef, cheese, and a biscuit base. Perfect for busy weeknights or feeding a hungry crowd, this casserole is a crowd-pleaser that combines convenience with deliciousness. The taco seasoning adds a zesty twist, while the creamy cheese mixture ensures every bite is indulgent and satisfying.


  • 1 ½ pounds ground beef
  • 1 onion, minced
  • 1 taco seasoning packet
  • ½ cup sour cream
  • ½ cup mayonnaise
  • ½ cup shredded cheddar cheese, divided
  • ½ cup shredded pepper jack cheese, divided
  • One 4-ounce can diced green chilies, drained
  • 2 cups Bisquick
  • 1 cup water


Preparing the Oven and Skillet

  1. Preheat the Oven: Preheat your oven to 350°F (175°C).
  2. Cook the Beef: Heat a nonstick skillet over medium-high heat. Add the ground beef and taco seasoning. Cook until the beef is browned on all sides, breaking it up into crumbles as it cooks.
  3. Add Aromatics: Add the minced onion and diced green chilies to the skillet. Cook until the onion is tender and slightly browned, about 5 minutes.

Mixing the Cheese Layer

  1. Prepare the Cheese Mixture: In a medium bowl, combine the sour cream, mayonnaise, and half of each of the shredded cheddar cheese and shredded pepper jack cheese. Mix well and set aside.

Preparing the Biscuit Base

  1. Make the Biscuit Dough: In another bowl, combine the Bisquick and water. Stir until a soft dough forms.
  2. Spread the Dough: Spread the Bisquick dough evenly into a greased 9-by-13-inch casserole dish.

Assembling the Casserole

  1. Layer the Beef: Top the Bisquick dough with the cooked ground beef mixture, spreading it out evenly.
  2. Add the Cheese Mixture: Spread the sour cream and cheese mixture over the beef layer, making sure it’s evenly distributed.
  3. Top with Cheese: Sprinkle the remaining shredded cheddar cheese and shredded pepper jack cheese on top.


  1. Bake the Casserole: Bake in the preheated oven for 30 minutes, or until the casserole is bubbly and browned on top.
  2. Cool and Serve: Once done, remove the casserole from the oven and let it cool slightly before serving.
See also  Heaven On Earth Cake

Tips for the Perfect Cattle Drive Casserole

  • Even Cooking: Ensure the ground beef is broken into small, even crumbles to cook uniformly.
  • Creamy Layer: For a richer flavor, use full-fat sour cream and mayonnaise.
  • Spice Level: Adjust the spiciness by using mild, medium, or hot taco seasoning and cheese varieties.
  • Bisquick Dough: Make sure the dough is evenly spread to create a consistent base layer.


Can I Use a Different Type of Meat?

Yes, you can substitute ground beef with ground turkey, chicken, or even pork for a different flavor profile.

How Do I Store Leftovers?

Store any leftovers in an airtight container in the refrigerator for up to 3 days. Reheat in the oven at 350°F (175°C) until warmed through.

Can I Make This Casserole Ahead of Time?

Yes, you can assemble the casserole up to a day in advance. Cover and refrigerate it, then bake as directed when ready to serve.

What Can I Serve with Cattle Drive Casserole?

This casserole pairs well with a simple green salad, steamed vegetables, or a side of cornbread.

Can I Freeze Cattle Drive Casserole?

Yes, you can freeze the casserole after baking. Let it cool completely, then wrap tightly with plastic wrap and aluminum foil. Freeze for up to 3 months. Thaw in the refrigerator overnight and reheat in the oven.

Can I Add Vegetables to the Casserole?

Absolutely! You can add vegetables like bell peppers, corn, or black beans to the beef mixture for added nutrition and flavor.

By following this recipe and incorporating these tips, you’ll create a delicious and satisfying Cattle Drive Casserole that your family and friends will love. Enjoy this hearty and flavorful dish any night of the week!